人 ARNTL2 (NM_001248005) cDNA克隆

基本信息

Accession: NM_001248005
基因名称: ARNTL2
基因别名: CLIF; MOP9; BMAL2; PASD9; bHLHe6
基因描述: Homo sapiens aryl hydrocarbon receptor nuclear translocator-like 2 (ARNTL2), transcript variant 5, mRNA.
种属: Human
CDS区长度: 1623 (查看编码区序列)
翻译后氨基酸长度: 540 (查看氨基酸序列)
Transcript Variant: This variant (5) uses an alternate in-frame donor splice site, lacks two consecutive in-frame coding exons, and another exon in the 3' region that causes a frame-shift, compared to variant 1. This results in a shorter isoform (3) with a distinct C-terminus compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G124256 人 ARNTL2 (NM_001248005) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 ARNTL2 (NM_020183) cDNA克隆 transcript variant 1
人 ARNTL2 (NM_001248002) cDNA克隆 transcript variant 2
人 ARNTL2 (NM_001248003) cDNA克隆 transcript variant 3
人 ARNTL2 (NM_001248004) cDNA克隆 transcript variant 4
人 ARNTL2 (NM_001248005) cDNA克隆 transcript variant 5

基因简介

This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

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