人 NFATC1 (NM_001278673) cDNA克隆

基本信息

Accession: NM_001278673
基因名称: NFATC1
基因别名: NFAT2; NFATc; NF-ATC
基因描述: Homo sapiens nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATC1), transcript variant 10, mRNA.
种属: Human
CDS区长度: 1416 (查看编码区序列)
翻译后氨基酸长度: 471 (查看氨基酸序列)
Transcript Variant: This variant (10) has an alternate 5' terminal exon and lacks an internal exon in the 5' region, which results in a downstream translation start codon, compared to variant 6. The encoded isoform (J) is shorter at the N-terminus, compared to isoform F.

订购信息

产品编号 产品名称 载体 规格 价格
G122842 人 NFATC1 (NM_001278673) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 NFATC1 (NM_172390) cDNA克隆 transcript variant 1
人 NFATC1 (NM_001278673) cDNA克隆 transcript variant 10
人 NFATC1 (NM_006162) cDNA克隆 transcript variant 2
人 NFATC1 (NM_172387) cDNA克隆 transcript variant 3
人 NFATC1 (NM_172388) cDNA克隆 transcript variant 4
人 NFATC1 (NM_172389) cDNA克隆 transcript variant 5
人 NFATC1 (NM_001278669) cDNA克隆 transcript variant 6
人 NFATC1 (NM_001278670) cDNA克隆 transcript variant 7
人 NFATC1 (NM_001278672) cDNA克隆 transcript variant 8
人 NFATC1 (NM_001278675) cDNA克隆 transcript variant 9

基因简介

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]

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