人 ITGAM (NM_000632) cDNA克隆

基本信息

Accession: NM_000632
基因名称: ITGAM
基因别名: CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
基因描述: Homo sapiens integrin, alpha M (complement component 3 receptor 3 subunit) (ITGAM), transcript variant 2, mRNA.
种属: Human
CDS区长度: 3459 (查看编码区序列)
翻译后氨基酸长度: 1152 (查看氨基酸序列)
Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks one internal amino acid, compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G122464 人 ITGAM (NM_000632) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 ITGAM (NM_001145808) cDNA克隆 transcript variant 1
人 ITGAM (NM_000632) cDNA克隆 transcript variant 2

基因简介

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

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