人 VRK1 (NM_003384) cDNA克隆

Accession: NM_003384
基因名称: VRK1
基因别名: PCH1; PCH1A
基因描述: Homo sapiens vaccinia related kinase 1 (VRK1), mRNA.
种属: Human
CDS区长度: 1191 (查看编码区序列)
翻译后氨基酸长度: 396 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G122208 人 VRK1 (NM_003384) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]