The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
人 DNASE2B (NM_058248) cDNA克隆
| Accession: | NM_058248 |
|---|---|
| 基因名称: | DNASE2B |
| 基因别名: | DLAD |
| 基因描述: | Homo sapiens deoxyribonuclease II beta (DNASE2B), transcript variant 2, mRNA. |
| 种属: | Human |
| CDS区长度: | 462 (查看编码区序列) |
| 翻译后氨基酸长度: | 153 (查看氨基酸序列) |
| Transcript Variant: | This variant (2) lacks the first two exons present in transcript variant 1. However, it maintains the same reading frame and encodes an isoform (2) which is truncated at the N-terminus compared to isoform 1. Isoform 2 is specifically expressed in the lungs. |
| 人 DNASE2B (NM_021233) cDNA克隆 | transcript variant 1 |
| 人 DNASE2B (NM_058248) cDNA克隆 | transcript variant 2 |
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