人 OBSCN (NM_001098623) cDNA克隆

基本信息

Accession: NM_001098623
基因名称: OBSCN
基因别名: UNC89; ARHGEF30
基因描述: Homo sapiens obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (OBSCN), transcript variant 2, mRNA.
种属: Human
CDS区长度: 23907 (查看编码区序列)
翻译后氨基酸长度: 7968 (查看氨基酸序列)
Transcript Variant: This variant (2) differs in the 3' UTR and the 3' coding region, compared to variant 1. The resulting isoform (b) contains a distinct C-terminus, compared to isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G121843 人 OBSCN (NM_001098623) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 OBSCN (NM_052843) cDNA克隆 transcript variant 1
人 OBSCN (NM_001098623) cDNA克隆 transcript variant 2
人 OBSCN (NM_001271223) cDNA克隆 transcript variant IC

基因简介

The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

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