人 DDR1 (NM_001202521) cDNA克隆

基本信息

Accession: NM_001202521
基因名称: DDR1
基因别名: CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A
基因描述: Homo sapiens discoidin domain receptor tyrosine kinase 1 (DDR1), transcript variant 4, mRNA.
种属: Human
CDS区长度: 1527 (查看编码区序列)
翻译后氨基酸长度: 508 (查看氨基酸序列)
Transcript Variant: This variant (4) is missing an internal coding exon compared to variant 1. This results in a frame-shift, and early translation termination, rendering this transcript a candidate for nonsense-mediated mRNA decay (NMD). However, the encoded isoform (4, also known as DDR1d) is represented as it has been detected in vivo in several colon carcinoma cell lines (PMID:11344127). This isoform is truncated and lacks the catalytic tyrosine kinase domain, therefore, most likely lacks intrinsic tyrosine kinase activity. It may function in some other regulatory capacity.

订购信息

产品编号 产品名称 载体 规格 价格
G120107 人 DDR1 (NM_001202521) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 DDR1 (NM_001954) cDNA克隆 transcript variant 1
人 DDR1 (NM_013993) cDNA克隆 transcript variant 2
人 DDR1 (NM_013994) cDNA克隆 transcript variant 3
人 DDR1 (NM_001202521) cDNA克隆 transcript variant 4
人 DDR1 (NM_001202522) cDNA克隆 transcript variant 5
人 DDR1 (NM_001202523) cDNA克隆 transcript variant 6

基因简介

Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

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