人 PRR5 (NM_001017528) cDNA克隆

基本信息

Accession: NM_001017528
基因名称: PRR5
基因别名: PP610; PROTOR1; PROTOR-1; FLJ20185k
基因描述: Homo sapiens proline rich 5 (renal) (PRR5), transcript variant 3, mRNA.
种属: Human
CDS区长度: 1140 (查看编码区序列)
翻译后氨基酸长度: 379 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform (2).

订购信息

产品编号 产品名称 载体 规格 价格
G119728 人 PRR5 (NM_001017528) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 PRR5 (NM_181333) cDNA克隆 transcript variant 1
人 PRR5 (NM_015366) cDNA克隆 transcript variant 2
人 PRR5 (NM_001017528) cDNA克隆 transcript variant 3
人 PRR5 (NM_001017530) cDNA克隆 transcript variant 4
人 PRR5 (NM_001017529) cDNA克隆 transcript variant 5
人 PRR5 (NM_001198721) cDNA克隆 transcript variant 6

基因简介

This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]

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