人 KCNN2 (NM_170775) cDNA克隆

基本信息

Accession: NM_170775
基因名称: KCNN2
基因别名: SK2; hSK2; SKCA2; KCa2.2; SKCa 2
基因描述: Homo sapiens potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (KCNN2), transcript variant 2, mRNA.
种属: Human
CDS区长度: 696 (查看编码区序列)
翻译后氨基酸长度: 231 (查看氨基酸序列)
Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (b), which is shorter at the N-terminus compared to isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G119682 人 KCNN2 (NM_170775) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 KCNN2 (NM_021614) cDNA克隆 transcript variant 1
人 KCNN2 (NM_170775) cDNA克隆 transcript variant 2
人 KCNN2 (NM_001278204) cDNA克隆 transcript variant 3

基因简介

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

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