人 TOP1MT (NM_001258446) cDNA克隆

基本信息

Accession: NM_001258446
基因名称: TOP1MT
基因描述: Homo sapiens topoisomerase (DNA) I, mitochondrial (TOP1MT), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1512 (查看编码区序列)
翻译后氨基酸长度: 503 (查看氨基酸序列)
Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G119455 人 TOP1MT (NM_001258446) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 TOP1MT (NM_052963) cDNA克隆 transcript variant 1
人 TOP1MT (NM_001258446) cDNA克隆 transcript variant 2
人 TOP1MT (NM_001258447) cDNA克隆 transcript variant 3

基因简介

This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

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