人 PYHIN1 (NM_198928) cDNA克隆

基本信息

Accession: NM_198928
基因名称: PYHIN1
基因别名: IFIX; RP11-520H16.1
基因描述: Homo sapiens pyrin and HIN domain family, member 1 (PYHIN1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1452 (查看编码区序列)
翻译后氨基酸长度: 483 (查看氨基酸序列)
Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in a shorter isoform (alpha 2) missing a 9 aa protein segment compared to isoform alpha 1.

订购信息

产品编号 产品名称 载体 规格 价格
G118780 人 PYHIN1 (NM_198928) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 PYHIN1 (NM_152501) cDNA克隆 transcript variant 1
人 PYHIN1 (NM_198928) cDNA克隆 transcript variant 2
人 PYHIN1 (NM_198929) cDNA克隆 transcript variant 3
人 PYHIN1 (NM_198930) cDNA克隆 transcript variant 4

基因简介

The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

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