人 PIM1 (NM_001243186) cDNA克隆

基本信息

Accession: NM_001243186
基因名称: PIM1
基因别名: PIM
基因描述: Homo sapiens pim-1 oncogene (PIM1), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1215 (查看编码区序列)
翻译后氨基酸长度: 404 (查看氨基酸序列)
Transcript Variant: This variant (1) encodes two isoforms resulting from the use of alternate in-frame, translation initiation codons. This RefSeq represents the longer isoform (1, also known as Pim-1L) derived from the use of an upstream non-AUG (CUG) start codon (at nt 158-160). Pim-1L has been shown to localize primarily on the plasma membrane, and to confer resistance to chemotherapeutic drugs in prostate cancer cells (PMID:16186805).

订购信息

产品编号 产品名称 载体 规格 价格
G118403 人 PIM1 (NM_001243186) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 PIM1 (NM_002648) cDNA克隆 transcript variant 1
人 PIM1 (NM_001243186) cDNA克隆 transcript variant 1

基因简介

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]

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