人 RASGRF1 (NM_153815) cDNA克隆

基本信息

Accession: NM_153815
基因名称: RASGRF1
基因别名: GNRP; GRF1; CDC25; GRF55; CDC25L; H-GRF55; PP13187; ras-GRF1
基因描述: Homo sapiens Ras protein-specific guanine nucleotide-releasing factor 1 (RASGRF1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1470 (查看编码区序列)
翻译后氨基酸长度: 489 (查看氨基酸序列)
Transcript Variant: This variant (2) lacks multiple 5' exon, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a much shorter N-terminus, as compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G118064 人 RASGRF1 (NM_153815) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 RASGRF1 (NM_002891) cDNA克隆 transcript variant 1
人 RASGRF1 (NM_153815) cDNA克隆 transcript variant 2
人 RASGRF1 (NM_001145648) cDNA克隆 transcript variant 3

基因简介

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]

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