人 TRAF1 (NM_001190947) cDNA克隆

基本信息

Accession: NM_001190947
基因名称: TRAF1
基因别名: EBI6; MGC:10353
基因描述: Homo sapiens TNF receptor-associated factor 1 (TRAF1), transcript variant 3, mRNA.
种属: Human
CDS区长度: 885 (查看编码区序列)
翻译后氨基酸长度: 294 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G117811 人 TRAF1 (NM_001190947) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 TRAF1 (NM_005658) cDNA克隆 transcript variant 1
人 TRAF1 (NM_001190945) cDNA克隆 transcript variant 2
人 TRAF1 (NM_001190947) cDNA克隆 transcript variant 3

基因简介

The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

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