人 WISP2 (NM_003881) cDNA克隆

Accession: NM_003881
基因名称: WISP2
基因别名: CCN5; CT58; CTGF-L
基因描述: Homo sapiens WNT1 inducible signaling pathway protein 2 (WISP2), mRNA.
种属: Human
CDS区长度: 753 (查看编码区序列)
翻译后氨基酸长度: 250 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G117205 人 WISP2 (NM_003881) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]