人 TAX1BP1 (NM_001206902) cDNA克隆

基本信息

Accession: NM_001206902
基因名称: TAX1BP1
基因别名: T6BP; TXBP151; CALCOCO3
基因描述: Homo sapiens Tax1 (human T-cell leukemia virus type I) binding protein 1 (TAX1BP1), transcript variant 4, mRNA.
种属: Human
CDS区长度: 1773 (查看编码区序列)
翻译后氨基酸长度: 590 (查看氨基酸序列)
Transcript Variant: This variant (4) is missing an internal coding exon compared to variant 1. This results in the creation of an upstream ORF (uORF), translation of which will render this transcript a candidate for nonsense-mediated mRNA decay (NMD). However, since the uORF has a weak Kozak signal, translation from an in-frame downstream AUG is possible by leaky scanning, resulting in an isoform (3) with a shorter N-terminus and missing an internal protein segment compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G117038 人 TAX1BP1 (NM_001206902) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 TAX1BP1 (NM_006024) cDNA克隆 transcript variant 1
人 TAX1BP1 (NM_001079864) cDNA克隆 transcript variant 2
人 TAX1BP1 (NM_001206901) cDNA克隆 transcript variant 3
人 TAX1BP1 (NM_001206902) cDNA克隆 transcript variant 4

基因简介

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

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