人 DBI (NM_001282635) cDNA克隆

基本信息

Accession: NM_001282635
基因名称: DBI
基因别名: EP; ACBP; ACBD1; CCK-RP
基因描述: Homo sapiens diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) (DBI), transcript variant 10, mRNA.
种属: Human
CDS区长度: 315 (查看编码区序列)
翻译后氨基酸长度: 104 (查看氨基酸序列)
Transcript Variant: This variant (10) differs in the 5' UTR and 5' coding region, compared to variant 5. The resulting isoform (1) has a shorter and distinct N-terminus, compared to isoform 5. Variants 1, 7, 8, 9, and 10 encode the same isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G116997 人 DBI (NM_001282635) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 DBI (NM_020548) cDNA克隆 transcript variant 1
人 DBI (NM_001282635) cDNA克隆 transcript variant 10
人 DBI (NM_001282636) cDNA克隆 transcript variant 11
人 DBI (NM_001079863) cDNA克隆 transcript variant 2
人 DBI (NM_001079862) cDNA克隆 transcript variant 3
人 DBI (NM_001178017) cDNA克隆 transcript variant 4
人 DBI (NM_001178041) cDNA克隆 transcript variant 5
人 DBI (NM_001178043) cDNA克隆 transcript variant 6
人 DBI (NM_001178042) cDNA克隆 transcript variant 7
人 DBI (NM_001282633) cDNA克隆 transcript variant 8
人 DBI (NM_001282634) cDNA克隆 transcript variant 9

基因简介

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

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