人 IL18BP (NM_173044) cDNA克隆

基本信息

Accession: NM_173044
基因名称: IL18BP
基因别名: IL18BPa
基因描述: Homo sapiens interleukin 18 binding protein (IL18BP), transcript variant D, mRNA.
种属: Human
CDS区长度: 492 (查看编码区序列)
翻译后氨基酸长度: 163 (查看氨基酸序列)
Transcript Variant: This variant (D) differs in the 5' UTR and uses an alternate donor splice site at the penultimate coding exon compared to variant A. This results in a frame-shift and a shorter isoform (d, also known as IL-18BPd) with a distinct C-terminus compared to isoform a. This isoform lacks the ability to bind IL-18 (PMID:10655506).

订购信息

产品编号 产品名称 载体 规格 价格
G116498 人 IL18BP (NM_173044) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 IL18BP (NM_173042) cDNA克隆 transcript variant A
人 IL18BP (NM_005699) cDNA克隆 transcript variant C
人 IL18BP (NM_173044) cDNA克隆 transcript variant D
人 IL18BP (NM_001039659) cDNA克隆 transcript variant E
人 IL18BP (NM_001039660) cDNA克隆 transcript variant F
人 IL18BP (NM_001145057) cDNA克隆 transcript variant G
人 IL18BP (NM_001145055) cDNA克隆 transcript variant H

基因简介

The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

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