人 GFRA2 (NM_001165038) cDNA克隆

基本信息

Accession: NM_001165038
基因名称: GFRA2
基因别名: NTNRA; RETL2; TRNR2; GDNFRB; NRTNR-ALPHA
基因描述: Homo sapiens GDNF family receptor alpha 2 (GFRA2), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1080 (查看编码区序列)
翻译后氨基酸长度: 359 (查看氨基酸序列)
Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment near the N-terminus, compared to isoform a. It is not known if this variant is targeted to the cell membrane.

订购信息

产品编号 产品名称 载体 规格 价格
G116131 人 GFRA2 (NM_001165038) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 GFRA2 (NM_001495) cDNA克隆 transcript variant 1
人 GFRA2 (NM_001165038) cDNA克隆 transcript variant 2
人 GFRA2 (NM_001165039) cDNA克隆 transcript variant 3

基因简介

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

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