人 PKN1 (NM_002741) cDNA克隆

基本信息

Accession: NM_002741
基因名称: PKN1
基因别名: DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA
基因描述: Homo sapiens protein kinase N1 (PKN1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 2829 (查看编码区序列)
翻译后氨基酸长度: 942 (查看氨基酸序列)
Transcript Variant: This variant (2) uses an alternate exon at the 5' end compared to variant 1, which includes a part of the coding region. The resulting isoform (2) has a distinct and shorter N-terminus, as compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G114235 人 PKN1 (NM_002741) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 PKN1 (NM_213560) cDNA克隆 transcript variant 1
人 PKN1 (NM_002741) cDNA克隆 transcript variant 2

基因简介

The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

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