人 ITGAL (NM_001114380) cDNA克隆

基本信息

Accession: NM_001114380
基因名称: ITGAL
基因别名: CD11A; LFA-1; LFA1A
基因描述: Homo sapiens integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) (ITGAL), transcript variant 2, mRNA.
种属: Human
CDS区长度: 3261 (查看编码区序列)
翻译后氨基酸长度: 1086 (查看氨基酸序列)
Transcript Variant: This variant (2) lacks an alternate in-frame segment and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G114119 人 ITGAL (NM_001114380) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 ITGAL (NM_002209) cDNA克隆 transcript variant 1
人 ITGAL (NM_001114380) cDNA克隆 transcript variant 2

基因简介

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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