人 TTK (NM_001166691) cDNA克隆

基本信息

Accession: NM_001166691
基因名称: TTK
基因别名: ESK; PYT; CT96; MPH1; MPS1; MPS1L1
基因描述: Homo sapiens TTK protein kinase (TTK), transcript variant 2, mRNA.
种属: Human
CDS区长度: 2571 (查看编码区序列)
翻译后氨基酸长度: 856 (查看氨基酸序列)
Transcript Variant: This variant (2) uses alternate in-frame splice sites in the 5' UTR and in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G113984 人 TTK (NM_001166691) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 TTK (NM_003318) cDNA克隆 transcript variant 1
人 TTK (NM_001166691) cDNA克隆 transcript variant 2

基因简介

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

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