人 IFI16 (NM_001206567) cDNA克隆

基本信息

Accession: NM_001206567
基因名称: IFI16
基因别名: PYHIN2; IFNGIP1
基因描述: Homo sapiens interferon, gamma-inducible protein 16 (IFI16), transcript variant 1, mRNA.
种属: Human
CDS区长度: 2190 (查看编码区序列)
翻译后氨基酸长度: 729 (查看氨基酸序列)
Transcript Variant: This variant (1) lacks an in-frame exon in the 5' coding region and has an additional in-frame exon in the 3' coding region, compared to variant 2. The additional exon is described as exon 7a in PMID:9718316. The resulting isoform (1) is of the same size but lacks a segment in the N-terminal region and has an additional segment in the C-terminal region, compared to isoform 2. Note the CDS was annotated to initiate translation from an in-frame downstream AUG, as it is flanked by a strong Kozak signal, and is better conserved than the upstream AUG located 4 codons upstream.

订购信息

产品编号 产品名称 载体 规格 价格
G113914 人 IFI16 (NM_001206567) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 IFI16 (NM_001206567) cDNA克隆 transcript variant 1
人 IFI16 (NM_005531) cDNA克隆 transcript variant 2

基因简介

This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

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