人 POT1 (NM_001042594) cDNA克隆

基本信息

Accession: NM_001042594
基因名称: POT1
基因别名: HPOT1
基因描述: Homo sapiens protection of telomeres 1 (POT1), transcript variant 4, mRNA.
种属: Human
CDS区长度: 1512 (查看编码区序列)
翻译后氨基酸长度: 503 (查看氨基酸序列)
Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (5, also known as POT1-55) has a shorter N-terminus, compared to isoform 1. There are currently no publicly available full-length transcripts representing this variant, but it is supported by data in PMIDs 12391173 and 15973431.

订购信息

产品编号 产品名称 载体 规格 价格
G113689 人 POT1 (NM_001042594) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 POT1 (NM_015450) cDNA克隆 transcript variant 1
人 POT1 (NM_001042594) cDNA克隆 transcript variant 4

基因简介

This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

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