人 RUNX1T1 (NM_001198629) cDNA克隆

基本信息

Accession: NM_001198629
基因名称: RUNX1T1
基因别名: CDR; ETO; MTG8; AML1T1; ZMYND2; CBFA2T1
基因描述: Homo sapiens runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1), transcript variant 10, mRNA.
种属: Human
CDS区长度: 1815 (查看编码区序列)
翻译后氨基酸长度: 604 (查看氨基酸序列)
Transcript Variant: This variant (10) utilizes two alternate exons in the 5' UTR and coding region compared to variant 1. The resulting protein (isoform B, also known as MTG8b) has a longer and distinct N-terminus, compared to isoform A. Variants 2 and 7-12 all encode isoform B.

订购信息

产品编号 产品名称 载体 规格 价格
G113592 人 RUNX1T1 (NM_001198629) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 RUNX1T1 (NM_004349) cDNA克隆 transcript variant 1
人 RUNX1T1 (NM_001198629) cDNA克隆 transcript variant 10
人 RUNX1T1 (NM_001198630) cDNA克隆 transcript variant 11
人 RUNX1T1 (NM_001198631) cDNA克隆 transcript variant 12
人 RUNX1T1 (NM_001198633) cDNA克隆 transcript variant 13
人 RUNX1T1 (NM_001198634) cDNA克隆 transcript variant 14
人 RUNX1T1 (NM_001198679) cDNA克隆 transcript variant 15
人 RUNX1T1 (NM_175634) cDNA克隆 transcript variant 2
人 RUNX1T1 (NM_175635) cDNA克隆 transcript variant 3
人 RUNX1T1 (NM_175636) cDNA克隆 transcript variant 4
人 RUNX1T1 (NM_001198625) cDNA克隆 transcript variant 5
人 RUNX1T1 (NM_001198632) cDNA克隆 transcript variant 6
人 RUNX1T1 (NM_001198626) cDNA克隆 transcript variant 7
人 RUNX1T1 (NM_001198627) cDNA克隆 transcript variant 8
人 RUNX1T1 (NM_001198628) cDNA克隆 transcript variant 9

基因简介

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

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