The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
人 NOL6 (NM_022917) cDNA克隆
| Accession: | NM_022917 |
|---|---|
| 基因名称: | NOL6 |
| 基因别名: | NRAP; UTP22; bA311H10.1 |
| 基因描述: | Homo sapiens nucleolar protein 6 (RNA-associated) (NOL6), transcript variant alpha, mRNA. |
| 种属: | Human |
| CDS区长度: | 3441 (查看编码区序列) |
| 翻译后氨基酸长度: | 1146 (查看氨基酸序列) |
| Transcript Variant: | This variant (alpha) encodes the longest isoform (alpha), also known as the long isoform. |
| 人 NOL6 (NM_022917) cDNA克隆 | transcript variant alpha |
| 人 NOL6 (NM_139235) cDNA克隆 | transcript variant gamma |
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