人 DDIT3 (NM_004083) cDNA克隆

基本信息

Accession: NM_004083
基因名称: DDIT3
基因别名: CHOP; CEBPZ; CHOP10; CHOP-10; GADD153
基因描述: Homo sapiens DNA-damage-inducible transcript 3 (DDIT3), transcript variant 5, mRNA.
种属: Human
CDS区长度: 510 (查看编码区序列)
翻译后氨基酸长度: 169 (查看氨基酸序列)
Transcript Variant: This variant (5) lacks an internal segment in the 5' region, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G113125 人 DDIT3 (NM_004083) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 DDIT3 (NM_001195053) cDNA克隆 transcript variant 1
人 DDIT3 (NM_001195054) cDNA克隆 transcript variant 2
人 DDIT3 (NM_001195055) cDNA克隆 transcript variant 3
人 DDIT3 (NM_001195056) cDNA克隆 transcript variant 4
人 DDIT3 (NM_004083) cDNA克隆 transcript variant 5
人 DDIT3 (NM_001195057) cDNA克隆 transcript variant 6

基因简介

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]

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