人 PES1 (NM_001282327) cDNA克隆

Accession: NM_001282327
基因名称: PES1
基因别名: PES
基因描述: Homo sapiens pescadillo ribosomal biogenesis factor 1 (PES1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1350 (查看编码区序列)
翻译后氨基酸长度: 449 (查看氨基酸序列)
Transcript Variant: This variant (2) represents use of an alternate promoter and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream AUG, and the resulting isoform (3) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same protein (isoform 3).
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G112377 人 PES1 (NM_001282327) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]