人 RNF8 (NM_183078) cDNA克隆

基本信息

Accession: NM_183078
基因名称: RNF8
基因别名: hRNF8
基因描述: Homo sapiens ring finger protein 8, E3 ubiquitin protein ligase (RNF8), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1347 (查看编码区序列)
翻译后氨基酸长度: 448 (查看氨基酸序列)
Transcript Variant: This variant (2) lacks an exon within the coding region, which leads to a translation frameshift, as compared to variant 1. The resulting isoform (2) contains a distinct and shorter C-terminus, as compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G111592 人 RNF8 (NM_183078) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 RNF8 (NM_003958) cDNA克隆 transcript variant 1
人 RNF8 (NM_183078) cDNA克隆 transcript variant 2

基因简介

The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

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