人 OGDH (NM_001003941) cDNA克隆

基本信息

Accession: NM_001003941
基因名称: OGDH
基因别名: E1k; OGDC; AKGDH
基因描述: Homo sapiens oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (OGDH), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1284 (查看编码区序列)
翻译后氨基酸长度: 427 (查看氨基酸序列)
Transcript Variant: This variant (2) uses an alternate splice site in the 3' end of coding region, compared to variant 1. Variant 2 encodes isoform 2 which has a shorter and distinct C-terminus, compared to isoform 1. Variant 2 is supported by transcriptional evidence although the protein product is predicted.

订购信息

产品编号 产品名称 载体 规格 价格
G110927 人 OGDH (NM_001003941) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 OGDH (NM_002541) cDNA克隆 transcript variant 1
人 OGDH (NM_001003941) cDNA克隆 transcript variant 2
人 OGDH (NM_001165036) cDNA克隆 transcript variant 3

基因简介

This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]

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