人 GPBAR1 (NM_001077194) cDNA克隆

基本信息

Accession: NM_001077194
基因名称: GPBAR1
基因别名: BG37; TGR5; M-BAR; GPCR19; GPR131
基因描述: Homo sapiens G protein-coupled bile acid receptor 1 (GPBAR1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 993 (查看编码区序列)
翻译后氨基酸长度: 330 (查看氨基酸序列)
Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.

订购信息

产品编号 产品名称 载体 规格 价格
G109825 人 GPBAR1 (NM_001077194) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 GPBAR1 (NM_001077191) cDNA克隆 transcript variant 1
人 GPBAR1 (NM_001077194) cDNA克隆 transcript variant 2
人 GPBAR1 (NM_170699) cDNA克隆 transcript variant 3

基因简介

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

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