人 LIMS1 (NM_001193488) cDNA克隆

基本信息

Accession: NM_001193488
基因名称: LIMS1
基因别名: PINCH; PINCH1; PINCH-1
基因描述: Homo sapiens LIM and senescent cell antigen-like domains 1 (LIMS1), transcript variant 3, mRNA.
种属: Human
CDS区长度: 978 (查看编码区序列)
翻译后氨基酸长度: 325 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

订购信息

产品编号 产品名称 载体 规格 价格
G109755 人 LIMS1 (NM_001193488) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 LIMS1 (NM_001193485) cDNA克隆 transcript variant 1
人 LIMS1 (NM_004987) cDNA克隆 transcript variant 2
人 LIMS1 (NM_001193488) cDNA克隆 transcript variant 3
人 LIMS1 (NM_001193482) cDNA克隆 transcript variant 4
人 LIMS1 (NM_001193483) cDNA克隆 transcript variant 5
人 LIMS1 (NM_001193484) cDNA克隆 transcript variant 6

基因简介

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

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