人 NBL1 (NM_001204085) cDNA克隆

基本信息

Accession: NM_001204085
基因名称: NBL1
基因别名: NB; DAN; NO3; DAND1; D1S1733E
基因描述: Homo sapiens neuroblastoma 1, DAN family BMP antagonist (NBL1), transcript variant 4, mRNA.
种属: Human
CDS区长度: 546 (查看编码区序列)
翻译后氨基酸长度: 181 (查看氨基酸序列)
Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 3, 4, 6, 7, and 8 encode the same isoform (2).

订购信息

产品编号 产品名称 载体 规格 价格
G107913 人 NBL1 (NM_001204085) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 NBL1 (NM_182744) cDNA克隆 transcript variant 1
人 NBL1 (NM_005380) cDNA克隆 transcript variant 2
人 NBL1 (NM_001204084) cDNA克隆 transcript variant 3
人 NBL1 (NM_001204085) cDNA克隆 transcript variant 4
人 NBL1 (NM_001204086) cDNA克隆 transcript variant 5
人 NBL1 (NM_001278164) cDNA克隆 transcript variant 6
人 NBL1 (NM_001278165) cDNA克隆 transcript variant 7
人 NBL1 (NM_001278166) cDNA克隆 transcript variant 8

基因简介

This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]

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