人 OPTN (NM_001008212) cDNA克隆

基本信息

Accession: NM_001008212
基因名称: OPTN
基因别名: NRP; FIP2; HIP7; HYPL; ALS12; GLC1E; TFIIIA-INTP
基因描述: Homo sapiens optineurin (OPTN), transcript variant 3, mRNA.
种属: Human
CDS区长度: 1734 (查看编码区序列)
翻译后氨基酸长度: 577 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.

订购信息

产品编号 产品名称 载体 规格 价格
G107018 人 OPTN (NM_001008212) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 OPTN (NM_001008211) cDNA克隆 transcript variant 1
人 OPTN (NM_021980) cDNA克隆 transcript variant 2
人 OPTN (NM_001008212) cDNA克隆 transcript variant 3
人 OPTN (NM_001008213) cDNA克隆 transcript variant 4

基因简介

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

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