人 DENND1B (NM_001195216) cDNA克隆

基本信息

Accession: NM_001195216
基因名称: DENND1B
基因别名: FAM31B; C1ORF18; C1orf218; RP11-53I24.2
基因描述: Homo sapiens DENN/MADD domain containing 1B (DENND1B), transcript variant 4, mRNA.
种属: Human
CDS区长度: 231 (查看编码区序列)
翻译后氨基酸长度: 76 (查看氨基酸序列)
Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 3. The resulting isoform (4) has a distinct C-terminus and is shorter than isoform 3.

订购信息

产品编号 产品名称 载体 规格 价格
G106453 人 DENND1B (NM_001195216) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 DENND1B (NM_144977) cDNA克隆 transcript variant 2
人 DENND1B (NM_001195215) cDNA克隆 transcript variant 3
人 DENND1B (NM_001195216) cDNA克隆 transcript variant 4

基因简介

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]

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