人 MCM7 (NM_001278595) cDNA克隆

基本信息

Accession: NM_001278595
基因名称: MCM7
基因别名: MCM2; CDC47; P85MCM; P1CDC47; PNAS146; P1.1-MCM3
基因描述: Homo sapiens minichromosome maintenance complex component 7 (MCM7), transcript variant 3, mRNA.
种属: Human
CDS区长度: 1632 (查看编码区序列)
翻译后氨基酸长度: 543 (查看氨基酸序列)
Transcript Variant: This variant (3) contains an additional internal segment, which results in translation initiation from an in-frame downstream AUG compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.

订购信息

产品编号 产品名称 载体 规格 价格
G106408 人 MCM7 (NM_001278595) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 MCM7 (NM_005916) cDNA克隆 transcript variant 1
人 MCM7 (NM_182776) cDNA克隆 transcript variant 2
人 MCM7 (NM_001278595) cDNA克隆 transcript variant 3

基因简介

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

相关产品