人 PTPN2 (NM_001207013) cDNA克隆

基本信息

Accession: NM_001207013
基因名称: PTPN2
基因别名: PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP
基因描述: Homo sapiens protein tyrosine phosphatase, non-receptor type 2 (PTPN2), transcript variant 4, mRNA.
种属: Human
CDS区长度: 1233 (查看编码区序列)
翻译后氨基酸长度: 410 (查看氨基酸序列)
Transcript Variant: This variant (4) contains an additional in-frame exon in the middle coding region and an alternate 3' region, which includes a part of the C-terminal coding region, when compared to variant 1. The resulting isoform (4) has an additional internal segment and a shorter and distinct C-terminus, as compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G106121 人 PTPN2 (NM_001207013) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 PTPN2 (NM_002828) cDNA克隆 transcript variant 1
人 PTPN2 (NM_080422) cDNA克隆 transcript variant 2
人 PTPN2 (NM_080423) cDNA克隆 transcript variant 3
人 PTPN2 (NM_001207013) cDNA克隆 transcript variant 4

基因简介

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]

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