人 GPBP1 (NM_001203246) cDNA克隆

基本信息

Accession: NM_001203246
基因名称: GPBP1
基因别名: GPBP; SSH6; VASCULIN
基因描述: Homo sapiens GC-rich promoter binding protein 1 (GPBP1), transcript variant 4, mRNA.
种属: Human
CDS区长度: 909 (查看编码区序列)
翻译后氨基酸长度: 302 (查看氨基酸序列)
Transcript Variant: This variant (4) is missing an exon in the 5' region compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and a much shorter isoform (4, also known as SSH6-beta) compared to isoform 1. This isoform has been reported to be more ubiquitously expressed compared to the vascular wall specific expression pattern of the longer isoforms (PMID:12842993).

订购信息

产品编号 产品名称 载体 规格 价格
G105178 人 GPBP1 (NM_001203246) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 GPBP1 (NM_022913) cDNA克隆 transcript variant 1
人 GPBP1 (NM_001127236) cDNA克隆 transcript variant 2
人 GPBP1 (NM_001127235) cDNA克隆 transcript variant 3
人 GPBP1 (NM_001203246) cDNA克隆 transcript variant 4

基因简介

This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

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