人 PRKCZ (NM_001033581) cDNA克隆

基本信息

Accession: NM_001033581
基因名称: PRKCZ
基因别名: PKC2; PKC-ZETA
基因描述: Homo sapiens protein kinase C, zeta (PRKCZ), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1230 (查看编码区序列)
翻译后氨基酸长度: 409 (查看氨基酸序列)
Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).

订购信息

产品编号 产品名称 载体 规格 价格
G104157 人 PRKCZ (NM_001033581) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 PRKCZ (NM_002744) cDNA克隆 transcript variant 1
人 PRKCZ (NM_001033581) cDNA克隆 transcript variant 2
人 PRKCZ (NM_001033582) cDNA克隆 transcript variant 3
人 PRKCZ (NM_001242874) cDNA克隆 transcript variant 4

基因简介

Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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