人 NSUN2 (NM_001193455) cDNA克隆

Accession: NM_001193455
基因名称: NSUN2
基因别名: MISU; MRT5; SAKI; TRM4
基因描述: Homo sapiens NOP2/Sun RNA methyltransferase family, member 2 (NSUN2), transcript variant 2, mRNA.
种属: Human
CDS区长度: 2199 (查看编码区序列)
翻译后氨基酸长度: 732 (查看氨基酸序列)
Transcript Variant: This variant (2) lacks an in-frame coding exon in the 5' region compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
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G104115 人 NSUN2 (NM_001193455) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011]