人 PRKAG1 (NM_001206710) cDNA克隆

基本信息

Accession: NM_001206710
基因名称: PRKAG1
基因别名: AMPKG
基因描述: Homo sapiens protein kinase, AMP-activated, gamma 1 non-catalytic subunit (PRKAG1), transcript variant 4, mRNA.
种属: Human
CDS区长度: 900 (查看编码区序列)
翻译后氨基酸长度: 299 (查看氨基酸序列)
Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) is shorter at the N-terminus, compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G103838 人 PRKAG1 (NM_001206710) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 PRKAG1 (NM_002733) cDNA克隆 transcript variant 1
人 PRKAG1 (NM_001206709) cDNA克隆 transcript variant 3
人 PRKAG1 (NM_001206710) cDNA克隆 transcript variant 4

基因简介

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

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