人 TPM3 (NM_001043351) cDNA克隆

基本信息

Accession: NM_001043351
基因名称: TPM3
基因别名: TM3; TM5; TRK; CFTD; NEM1; TM-5; TM30; CAPM1; TM30nm; TPMsk3; hscp30; OK/SW-cl.5
基因描述: Homo sapiens tropomyosin 3 (TPM3), transcript variant 4, mRNA.
种属: Human
CDS区长度: 747 (查看编码区序列)
翻译后氨基酸长度: 248 (查看氨基酸序列)
Transcript Variant: This variant (4) lacks an exon and contains an alternate exon in the central coding region, but maintains the reading frame, compared to variant 2. The encoded isoform (4, also known as Tm5NM2) is the same length as isoform 2 but differs in the sequence.

订购信息

产品编号 产品名称 载体 规格 价格
G103778 人 TPM3 (NM_001043351) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 TPM3 (NM_152263) cDNA克隆 transcript variant 1
人 TPM3 (NM_153649) cDNA克隆 transcript variant 2
人 TPM3 (NM_001043352) cDNA克隆 transcript variant 3
人 TPM3 (NM_001043351) cDNA克隆 transcript variant 4
人 TPM3 (NM_001043353) cDNA克隆 transcript variant 5
人 TPM3 (NM_001278188) cDNA克隆 transcript variant 6
人 TPM3 (NM_001278189) cDNA克隆 transcript variant 7
人 TPM3 (NM_001278190) cDNA克隆 transcript variant 8
人 TPM3 (NM_001278191) cDNA克隆 transcript variant 9

基因简介

This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

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