人 INSIG1 (NM_005542) cDNA克隆

基本信息

Accession: NM_005542
基因名称: INSIG1
基因别名: CL6; CL-6
基因描述: Homo sapiens insulin induced gene 1 (INSIG1), transcript variant 1, mRNA.
种属: Human
CDS区长度: 834 (查看编码区序列)
翻译后氨基酸长度: 277 (查看氨基酸序列)
Transcript Variant: This variant (1) represent the longest transcript and encodes the longest isoform (1).

订购信息

产品编号 产品名称 载体 规格 价格
G103761 人 INSIG1 (NM_005542) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 INSIG1 (NM_005542) cDNA克隆 transcript variant 1
人 INSIG1 (NM_198336) cDNA克隆 transcript variant 2
人 INSIG1 (NM_198337) cDNA克隆 transcript variant 3

基因简介

Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2009]

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