人 LAT (NM_014387) cDNA克隆

基本信息

Accession: NM_014387
基因名称: LAT
基因别名: LAT1; pp36
基因描述: Homo sapiens linker for activation of T cells (LAT), transcript variant 1, mRNA.
种属: Human
CDS区长度: 789 (查看编码区序列)
翻译后氨基酸长度: 262 (查看氨基酸序列)
Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence and contains an internal in-frame segment compared to variant 4. The resulting isoform (a) is shorter at the N-terminus and contains an internal segment compared to isoform d.

订购信息

产品编号 产品名称 载体 规格 价格
G103560 人 LAT (NM_014387) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 LAT (NM_014387) cDNA克隆 transcript variant 1
人 LAT (NM_001014987) cDNA克隆 transcript variant 2
人 LAT (NM_001014988) cDNA克隆 transcript variant 3
人 LAT (NM_001014989) cDNA克隆 transcript variant 4

基因简介

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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