人 UBE2A (NM_181762) cDNA克隆

Accession: NM_181762
基因名称: UBE2A
基因别名: UBC2; HHR6A; MRXSN; RAD6A; MRXS30
基因描述: Homo sapiens ubiquitin-conjugating enzyme E2A (UBE2A), transcript variant 2, mRNA.
种属: Human
CDS区长度: 369 (查看编码区序列)
翻译后氨基酸长度: 122 (查看氨基酸序列)
Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
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G103138 人 UBE2A (NM_181762) cDNA克隆 pDONR223 2ug质粒 点击询价

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]