人 RNF111 (NM_017610) cDNA克隆

基本信息

Accession: NM_017610
基因名称: RNF111
基因别名: ARK
基因描述: Homo sapiens ring finger protein 111 (RNF111), transcript variant 2, mRNA.
种属: Human
CDS区长度: 2961 (查看编码区序列)
翻译后氨基酸长度: 986 (查看氨基酸序列)
Transcript Variant: This variant (2) lacks an in-frame segment in the 3' coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G103064 人 RNF111 (NM_017610) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 RNF111 (NM_001270528) cDNA克隆 transcript variant 1
人 RNF111 (NM_017610) cDNA克隆 transcript variant 2
人 RNF111 (NM_001270529) cDNA克隆 transcript variant 3
人 RNF111 (NM_001270530) cDNA克隆 transcript variant 4

基因简介

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

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