人 XRCC4 (NM_022550) cDNA克隆

基本信息

Accession: NM_022550
基因名称: XRCC4
基因描述: Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4), transcript variant 3, mRNA.
种属: Human
CDS区长度: 1005 (查看编码区序列)
翻译后氨基酸长度: 334 (查看氨基酸序列)
Transcript Variant: This variant (3) is the longest transcript; it has an additional segment in the 5' UTR and lacks a small segment in the 3' coding region, as compared to variant 2. Both variants 1 and 3 encode the same isoform (1), which is shorter than isoform 2.

订购信息

产品编号 产品名称 载体 规格 价格
G101237 人 XRCC4 (NM_022550) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 XRCC4 (NM_003401) cDNA克隆 transcript variant 1
人 XRCC4 (NM_022406) cDNA克隆 transcript variant 2
人 XRCC4 (NM_022550) cDNA克隆 transcript variant 3

基因简介

The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq, Sep 2008]

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