人 BEST3 (NM_001282616) cDNA克隆

基本信息

Accession: NM_001282616
基因名称: BEST3
基因别名: VMD2L3
基因描述: Homo sapiens bestrophin 3 (BEST3), transcript variant 6, mRNA.
种属: Human
CDS区长度: 219 (查看编码区序列)
翻译后氨基酸长度: 72 (查看氨基酸序列)
Transcript Variant: This variant (6) lacks a portion of the 5' UTR and 5' coding region, uses a downstream in-frame start codon, and lacks several 3' exons but includes an alternate 3' terminal exon, compared to variant 1. The encoded isoform (5) is shorter at the N-terminus, has a distinct C-terminus and is significantly shorter than isoform 1. Both variants 5 and 6 encode isoform 5.

订购信息

产品编号 产品名称 载体 规格 价格
G100938 人 BEST3 (NM_001282616) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 BEST3 (NM_032735) cDNA克隆 transcript variant 1
人 BEST3 (NM_152439) cDNA克隆 transcript variant 2
人 BEST3 (NM_001282613) cDNA克隆 transcript variant 3
人 BEST3 (NM_001282614) cDNA克隆 transcript variant 4
人 BEST3 (NM_001282615) cDNA克隆 transcript variant 5
人 BEST3 (NM_001282616) cDNA克隆 transcript variant 6

基因简介

BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008]

相关产品