人 LASP1 (NM_001271608) cDNA克隆

基本信息

Accession: NM_001271608
基因名称: LASP1
基因别名: MLN50; Lasp-1
基因描述: Homo sapiens LIM and SH3 protein 1 (LASP1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 618 (查看编码区序列)
翻译后氨基酸长度: 205 (查看氨基酸序列)
Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. This variant represents translation initiation at an alternate AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a weak Kozak sequence and a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which results in an isoform (2) that has a distinct N-terminus and is shorter than isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G100886 人 LASP1 (NM_001271608) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 LASP1 (NM_006148) cDNA克隆 transcript variant 1
人 LASP1 (NM_001271608) cDNA克隆 transcript variant 2

基因简介

This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]

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