人 FCGR3A (NM_001127596) cDNA克隆

基本信息

Accession: NM_001127596
基因名称: FCGR3A
基因别名: CD16; FCG3; CD16A; FCGR3; IGFR3; FCR-10; FCRIII; FCGRIII; FCRIIIA
基因描述: Homo sapiens Fc fragment of IgG, low affinity IIIa, receptor (CD16a) (FCGR3A), transcript variant 5, mRNA.
种属: Human
CDS区长度: 762 (查看编码区序列)
翻译后氨基酸长度: 253 (查看氨基酸序列)
Transcript Variant: This variant (5) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks an internal residue, compared to isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G100853 人 FCGR3A (NM_001127596) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 FCGR3A (NM_000569) cDNA克隆 transcript variant 1
人 FCGR3A (NM_001127592) cDNA克隆 transcript variant 2
人 FCGR3A (NM_001127593) cDNA克隆 transcript variant 3
人 FCGR3A (NM_001127595) cDNA克隆 transcript variant 4
人 FCGR3A (NM_001127596) cDNA克隆 transcript variant 5

基因简介

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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